Targeting the RB tumor suppressor
in pancreatic cancer
The RB tumor suppressor is inactivated by
phosphorylation in most human cancer cells.
Students: Rita Abraham, Biology, 2017
Brixhilda Dedi, Biology, 2017
PI:
Nancy
Krucher,
Biology, PLV
Using our previously developed method of siRNA
mediated gene knockout to activate phosphatase
toward the tumor suppressor gene, RB, we
determined whether using this method could
improve upon treatment with Erlotinib, a pancreatic
cancer drug used clinically. As shown above, in
Panc1 pancreatic cancer cells, combination
treatment results in a greater reduction in cell
number than either treatment alone or compared to
controls.
